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Hormozgan University of Medical Sciences

Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice

(2017) Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice. Hormozgan Medical Journal.

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Official URL: http://hmj.hums.ac.ir/article-1-1695-en.html

Abstract

Introduction: The aim of this study was to compare the protective effects of two types of aerobic and intermittent training on breast cancer as a result of TGFβ protein, Smad-3, and MMP2 gene in female mice. Methods: In the experimental study, a total of 24 female BALB/c mice after Tumorigenesis by MC4-L2 cell line in the three groups; Control, Aerobic, and Intermittent training groups, and under standard conditions were studied. Aerobic continuous training group performed 60 minutes of running on a treadmill with intensity of 60-65 VO2max, 5 days a week and high-intensity intermittent program included six bouts alternates (3 minutes and 20 seconds with intensity of 85–90VO2max and a minute of recovery with intense 30-35VO2max between each alternate) for a period of 10 weeks. Data using one-way ANOVA and Tukey's test at a significance level of P<0.05 were analyzed. Results: High-intensity intermittent training significantly increased expression of Smad-3 (P<0.03), and protein TGF-β (P<0.000) and decreased the expression of MMP-2 (P<0.000) in tumor tissue than in the control group. Aerobic training also significantly increased the expression of Smad-3 (P<0.03) and protein TGF-β (P<0.000) and decreased the expression of MMP-2 (P<0.04) in tumor tissue than in the control group. No significant differences in gene expression Smad-3 and MMP-2 between training groups was observed (P<0.05), However, there was significant differences in the TGF-β protein between High-intensity intermittent training and aerobic training groups (P<0.05). Conclusion: It seems that high-intensity intermittent and aerobic continuous training can possibly be effective interventions to reduce breast cancer progression and there is not much difference between the effects of two types of training.

Item Type: Article
Keywords: Breast Cancer, Training, TGFβ, Smad, MMP2
Subjects: general
Divisions: Research Vice-Chancellor Department > Hormozgan Medical Journal
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/205

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