Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Research project #1743

(2016) اثرجنستین بربیان ژن سرکوبگرتومور E-cadherin در رده های سلولی ALL و مطالعه اثر القایی آن بر آنزیم های تغییر دهنده هیستون. completed.

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Title

The impact of Genistein on expression of Tumor Suppressor gene E-cadherin in ALL through its inducing effect on Histon modification

Abstract

Acute lymphoblastic leukemia (ALL) dominates as an acute hematological malignancy in children; however the disease can appear at any age(1) ALL and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms. (2) The onset may be insidious or acute. Fatigue, lethargy, persistent fever, bleeding manifestations, bone and joint pain are the most common presenting features. .(1) B-precursor ALL is the most common form of acute leukemia in children and thus represents the most common malignancy of childhood

Item Type: Research project
Subjects: HEMATOLOGY
molecular Genetics
genetic
pharmacology
hematology oncology
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مرکز تحقیقات پزشکی مولکولی
URI: http://eprints.hums.ac.ir/id/eprint/1743

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