Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Iron Deficiency Anemia and Immune Deviation in Recurrent Vulvovaginal Candidiasis

(2013) Iron Deficiency Anemia and Immune Deviation in Recurrent Vulvovaginal Candidiasis. Iran J Immunol.

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Abstract

The relationship between states of Iron Deficiency Anemia (IDA) and susceptibility to infections remains controversial. A predominant Th1 response leads to resistance against recurrent vulvovaginal candidiasis (RVVC) whereas a Th2 response exacerbates the disease. Objective: To investigate the possible effect of iron deficiency on the host’s susceptibility to disease as a result of the Th1/Th2 cytokine polarization. Methods: We conducted a case-control study of 92 women in 4 groups based on strict inclusion and exclusion criteria: RVVC+IDA+ group, consisted of 23 women with RVVC and IDA. RVVC+ IDA- group consisted of 23 women with RVVC without IDA. RVVC-IDA+ group consisted of 23 women without RVVC and with IDA and RVVCIDA- group, consisted of 23 healthy women. The iron parameters and key cytokines (IFN-γ, IL-10, IL-12, IL-4) were measured in blood samples. Results: Comparison of IL-4 production between RVVC+ IDA+ (12.2 ± 1.3 pg/ml) and RVVC+ IDA- (2.4 ± 4.0 pg/ml) groups (p=0.044), between RVVC- IDA+ (14.6 ± 1.7 pg/ml) and RVVC- IDA- (1.28 ± 3.6 pg/ml) groups (p=0.006), between RVVC- IDA+ (14.6 ± 1.7 pg/ml) and RVVC+ IDA- (2.4 ± 4.0 pg/ml) groups (p=0.009) and also between RVVC+ IDA+ and RVVC- IDA- (1.28 ± 3.6 pg/ml) groups (p=0.03) showed significant differences. We found a significant positive correlation between IL-4 and TIBC (p=0.046) and between serum IL-10 and Hb levels (p=0.041) in the RVVC+ IDA- group. There was also a significant negative correlation between serum IL-4 and levels of SI (p=0.041) in the RVVC- IDA- group. Conclusion: It seems that IDA determines the balance between and the intensity of Th1 and Th2 forms of immune response, and leads to a deviation toward Th2 response which could contribute to recurrence of candidiasis.

Item Type: Article
Keywords: Cytokine, Iron Deficiency, Recurrent Vulvovaginal Candidiasis, Th1/Th2
Subjects: HEMATOLOGY
infectious diseases
obstetrics and gynecology
Divisions: Research Vice-Chancellor Department > Infectious and Tropical Diseases Research Center
Depositing User: مركز تحقيقات بيماريهاي عفوني
URI: http://eprints.hums.ac.ir/id/eprint/1539

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