Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Research project #1369

(2016) اثرجنستین بربیان ژن سرکوبگرتومورBTG3 در رده های سلولی ALL و مطالعه اثر القایی آن بر آنزیم ها. completed.

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Title

The impact of Genistein on expression of Tumor Suppressor gene BTG3 in ALL through its inducing effect on Histon modification

Abstract

Acute lymphoblastic leukemia, is the most common form of cancer in children, comprises approximately 30 percent of all childhood malignancies.The peak incidence occurs between two and five years of age. approximately 2500 to 3500 new cases of ALL are diagnosed in children each year in the United States with an incidence of 2.8 cases per 100,000.Acute lymphoblastic leukemia (ALL) is five times more common than acute myeloid leukemia (AML). Certain genetic and immunodeficiency syndromes (e.g, Down syndrome, Neurofibromatosis type 1, Bloom syndrome, and ataxia telangiectasia) place children at higher risk for ALL(1). While survival rates have improved dramatically, this malignancy still accounts for nearly one quarter of all deaths from childhood cancers. Even, It appears the incidence of childhood leukemia is increasing. Acute lymphoblastic leukemia (ALL) is a heterogeneous cancer that is characterized by rapid and uncontrolled proliferation of immature B- or T-lymphoid precursors(2)

Item Type: Research project
Subjects: molecular Genetics
genetic
pharmacology
hematology oncology
pediatric
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مرکز تحقیقات پزشکی مولکولی
URI: http://eprints.hums.ac.ir/id/eprint/1369

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