Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Research project #1356

(2016) بررسی ارتباط فاکتور انژیوژنیک Flt1و فرم محلول ان با پره اکلامپسی. completed.

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Title

Evaluation of association between angiogenic factor Flt1 and its soluble form with Preeclampsia

Abstract

Preeclampsia is a common pregnancy complication and leading cause of maternal and infant morbidity and mortality worldwide. Pre-eclampsia is a pregnancy complication characterized by hypertension and proteinuria after 20 weeks of gestation. Pre-eclampsia is a multi-system disorder that is unique to human pregnancy, affecting 5–7% of pregnancies worldwide (1). In fact, pre-eclampsia is polymorphic in nature, and virtually every organ system can be affected, thus predisposing women to serious complications, including disseminated intravascular coagulation, abruptio-placentae, cerebral hemorrhage, acute renal failure, circulating collapse, HELLP syndrome (hemolysis, elevated liver enzymes and thrombocytopenia), liver failure, cerebral edema with seizures and rarely death (2). Potential fetal complications include fetal growth restriction (FGR), prematurity and death (3) .An important pathway which is altered in preeclampsia is angiogenesis. Angiogenesis happens early in pregnancy and insufficient angiogenesis is characteristic of pre-clampsia (4) by contributing to incomplete remodeling of uterine spiral arterioles and abnormal placental vascular development that are central to the pathogenesis of preeclampsia (5). Among the angiogenic factors expressed by the placenta , VEGF plays a central role. Vascular endothelial growth factor (VEGF) is a potent regulator of placental vascular function

Item Type: Research project
Subjects: surgery gynecology and obstetrics
molecular Genetics
genetic
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مرکز تحقیقات پزشکی مولکولی
URI: http://eprints.hums.ac.ir/id/eprint/1356

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