Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Research project #1203

(2014) مطالعه اثر نانوترکیب ماده جنیستین با نانو ذره پارامغناطیسی اکسید آهن به عنوان عامل شیمی درمانی بر علیه سرطان. completed.

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The impact of nano-conjugation of Geinstein to superparamagnetic iron-oxide nanoparticles as chemotherapeutic agent against cancer


One of the main goals of nanomedicine is to develop a nanocarrier that can selectively deliver anticancer drugs to target tumors and affect as few healthy cells as possible [1]. Targeting specific sites in vivo for the delivery of therapeutic compounds presents a major obstacle to the treatment of many diseases. Several drug-delivery technologies have emerged and a fascinating part of this field is the development of nanoscale drug delivery devices. Nanoparticles (NPs) have been developed as an important strategy to deliver conventional drugs, recombinant proteins, vaccines and more recently, nucleotides. NPs and other colloidal drug-delivery systems modify the kinetics, body distribution and drug release of an associated drug [2, 3]. Among the different types of nanoparticles, superparamagnetic iron-oxide nanoparticles (SPIONs) are considered to be promising candidates in cancer theranostics due to their superparamagnetic behavior and surface-modification properties. When the size of iron-oxide nanoparticles is reduced to afew nanometers (1–20 nm), they are forced to have a single domain and become superparamagnetic [4]. In addition, SPIONs are non-toxic as the iron from degraded NP cores accumulates into the natural iron stores of the body [5].

Item Type: Research project
molecular Genetics
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مرکز تحقیقات پزشکی مولکولی

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